Obesity, insulin resistance and type BETA ALANINE 2 diabetes are accompanied by a variety of systemic and tissue-specific metabolic defects, including inflammation, oxidative and endoplasmic reticulum stress, lipotoxicity, and mitochondrial dysfunction.Over the past 30 years, association studies and genetic manipulations, as well as lifestyle and p
BackgroundStaphylococcus aureus is one of the most important human pathogens and methicillin-resistant variants (MRSAs) are a major cause of hospital and community-acquired infection.We aimed to map the geographic distribution of the dominant clones that cause invasive infections in Europe.Methods and findingsIn each country, staphylococcal referen
Søren Løvstad Christensen1, Mette Kjoelby1,2, Lars Ehlers31Health Technology Assessment and Health Services Research, Centre for Public Health, Central Denmark Region, Denmark; 2School of Public Health, Aarhus University, Denmark; 3Health Economics and Management, Aalborg University, DenmarkObjective: The purpose of this study
Abstract The lack of targeted therapies for triple-negative breast cancer (TNBC) contributes to their high Oversized Panels mortality rates and high risk of relapse compared to other subtypes of breast cancer.Most TNBCs (75%) have downregulated the expression of CREB3L1 (cAMP-responsive element binding protein 3 like 1), a transcription factor and